Follow-up matters. A study of weight loss during treatment answers a different question from a study of what happens after treatment ends.
What was studied?
Budini and colleagues reviewed 48 studies of weight after GLP-1 treatment stopped. Their nonlinear model used six randomised trials involving 3,236 participants.
What did they find?
The analysis estimated that around 60% of the weight lost during treatment was regained within a year of stopping. This is a proportion of the weight previously lost, not 60% of a person's body weight.
Where does the uncertainty sit?
Beyond 52 weeks, the trajectory was extrapolated. The estimated plateau of 75.3% regain is a model projection, not a directly observed long-term outcome for every participant. Most included studies had a moderate risk of bias.
How to read the finding
Group averages cannot tell an individual exactly what will happen. This report does not establish a personal stopping or maintenance plan.
Funding and interests
No study funding was reported. The abstract records relevant industry relationships for some authors.
Read the source
Budini et al., EClinicalMedicine · DOI 10.1016/j.eclinm.2026.103796
Based on the published abstract and bibliographic record; this is not a full-paper critical appraisal.
This publication provides general information, not personalised medical advice. Discuss treatment decisions with an appropriately qualified clinician.